Neuroendocrine neoplasms of the digestive system- current classification and terminology
نویسندگان
چکیده
The system of classification and terminology neuroendocrine neoplasms (NENs), updated in 2017 by AJCC 2019 WHO, is now recommended for general use. This article a review this with respect to NENs the digestive tract. Within new system, two categories were introduced, differing morphology, clinical course treatment, as based on differentiation histological maturity grading (G). Among tract, well differentiated tumours, Ki-67 proliferation index below 20%, NET G1 G2, histologically resembling normal cells distinguished. Neuroendocrine above 20% – termed carcinoma NEC (poorly G3) found be heterogeneous. In every organ tract limited group tumours but typically less than 55% (well high grade was remaining poorly usually over 55%, classified (high carcinoma). NEC, groups distinguished large cell small carcinomas. By introducing molecular research, any confusion between G3 avoided. goblet-cell carcinoid appendix MiNEN, which should according criteria applied adenocarcinomas their respective organs are not discussed.
منابع مشابه
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ژورنال
عنوان ژورنال: Nowotwory
سال: 2021
ISSN: ['0029-540X', '2300-2115']
DOI: https://doi.org/10.5603/njo.2021.0005