Neuroendocrine neoplasms of the digestive system- current classification and terminology

نویسندگان

چکیده

The system of classification and terminology neuroendocrine neoplasms (NENs), updated in 2017 by AJCC 2019 WHO, is now recommended for general use. This article a review this with respect to NENs the digestive tract. Within new system, two categories were introdu­ced, differing morphology, clinical course treatment, as based on differentiation histological maturity grading (G). Among tract, well differentiated tumours, Ki-67 proliferation index below 20%, NET G1 G2, histologically resembling normal cells distinguished. Neuroendocrine above 20% – termed carcinoma NEC (poorly G3) found be heterogeneous. In every organ tract limited group tumours but typically less than 55% (well high grade was remaining poorly usually over 55%, classified (high carcinoma). NEC, groups distinguished large cell small carcinomas. By introducing molecular research, any confusion between G3 avoided. goblet-cell carcinoid appendix MiNEN, which should according criteria applied adenocarcinomas their respective organs are not discussed.

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ژورنال

عنوان ژورنال: Nowotwory

سال: 2021

ISSN: ['0029-540X', '2300-2115']

DOI: https://doi.org/10.5603/njo.2021.0005